The boundary value of the MoCA scale is 26 points for normal and cognitive impairment. The MoCA scale involves eight cognitive domains, including attention and concentration, executive function, memory, language, visuospatial skills, abstract thinking, computation, and orientation, with a total score of 30 ( Nasreddine et al., 2005). The MMSE score abnormal interpretation criteria varies according to the educational levels of the subjects ( Tombaugh and McIntyre, 1992). The MMSE scale covers six aspects, including orientation (time and place), registration, attention and calculation, recall, language (naming, retelling, listening and understanding, reading, and writing), and visual construction, with a total score of 30 ( Folstein et al., 1975). Currently, there are various neurological assessment scales in clinical practice ( Tsoi et al., 2015) the Mini-Mental State Examination (MMSE) ( Folstein et al., 1975) and the Montreal Cognitive Assessment (MoCA) ( Nasreddine et al., 2005) are the two most common ones. Neuropsychological assessment is used to assist in the diagnosis of AD and evaluate the efficacy of the treatment ( Ashford et al., 2006). Its two diagnostic neuropathological hallmarks are numerous extracellular deposits of amyloid-β (Aβ) plaques and neurofibrillary tangles ( Braak and Braak, 1996). This model could be useful for multi-centers clinical trials and meta-analysis.Īlzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive dysfunction and abnormal mental behavior ( Sperling et al., 2011). After applying the circle-arc method for equivalent conversion, the consistency analysis results of the original and the converted MoCA-BJ of the patients in group B of the total group, high education years subgroup, medium education years subgroup, and low education years subgroup were 0.891 ( P < 0.001), 0.894 ( P < 0.001), 0.781 ( P < 0.001), 0.909 ( P < 0.001), respectively, with high consistency and statistical significance.Ĭonclusion: We established and validated a model of MMSE-C and MoCA-BJ score conversion for Chinese patients with AD using the circle-arc method. ![]() Results: The results of the consistency analysis of MMSE-C and MoCA-BJ in group A showed that the correlation coefficients of the total group, high education years subgroup, medium education years subgroup, and low education years subgroup were 0.905 ( P < 0.001), 0.874 ( P < 0.001), 0.949 ( P < 0.001), and 0.874 ( P < 0.001), respectively, with high consistency and statistical significance. The MMSE-C data of the verification group was converted to MoCA-BJ according to the formula, and the consistency analysis of the original MoCA-BJ of the verification group and the converted MoCA-BJ was performed to verify the conversion model. The circle-arc method was used to convert the MMSE-C scores of the conversion groups into MoCA-BJ scores, and the conversion formula was generated. Consistency analysis of MMSE-C and MoCA-BJ scores of patients in the conversion groups was performed. Materials and methods: MMSE-C and MoCA-BJ scoring were performed on the enrolled patients with AD ( n = 332). Equivalent conversion of MMSE-C and MoCA-BJ scores is important for meta-analysis. 8Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, Chinaīackground: The Chinese version of the Mini-Mental State Examination (MMSE-C) and the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ) are the most commonly used scales to screen for Alzheimer’s disease (AD) among Chinese patients however, their consistency varies according to populations and languages.7Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.6Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China.5Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, China.4Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, China.3National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China.2Department of Neurology, Hainan General Hospital, Haikou, Hainan, China. ![]() 1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China. ![]() Lu Zhou 1† Zhichuan Lin 2† Bin Jiao 1,3,4,5,6 Xinxin Liao 7 Yafang Zhou 7 Hui Li 1 Lu Shen 1,3,4,5,6,8 Ling Weng 1,3*
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